教授、主任醫(yī)師
醫(yī)學(xué)博士,博士后,血液病學(xué)專家,博士研究生導(dǎo)師。
1. SCI 雜志 Anti-Cancer Drugs 編委( 2009 年 IF:2.23 )。
2. 教育部“中國科技論文在線”特邀評審專家。
3. British Journal of Hematology 、 International Journal of Cancer 、 Oncology 等多種雜志審稿人。
4. 國家自然科學(xué)基金及廣東省自然科學(xué)基金評審專家。
5. 歐洲腫瘤協(xié)會抗癌分會國際會員。
6. 廣東省中西醫(yī)結(jié)合學(xué)會常委。
7. 廣州市抗癌協(xié)會血液腫瘤分會常委。
獲獎情況
1.2004 年榮獲中山大學(xué)附屬三院優(yōu)秀中青年醫(yī)師獎,是中山大學(xué)“千百十人才工程”培養(yǎng)對象。
2. 2006-2007 年以來被美國 Who\'s who in The Medicine and Healthcare (世界醫(yī)學(xué)與健康護(hù)理名人錄)收錄。
3. 2006 年被評為教育部“新世紀(jì)優(yōu)秀人才”。
4. 2008 及 2009 年教育部“科技論文在線”優(yōu)秀通訊評審專家。
論 著:截至到目前為止,在國內(nèi)外核心期刊發(fā)表學(xué)術(shù)論文 50 余篇 ( 第一作者 ), 其中 SCI 收錄 20 余篇。
以第一或通訊作者發(fā)表的主要代表論文(均為 SCI 收錄)有:
1. Antibody directed lentiviral mediated double suicide gene therapy in MUC-1 positive leukemia in vitro and in vivo. Cell Transplant 2011(In Press)
2. PPARγ Agonist Suppresses TLR4 Expression and TNF-α Production in LPS Stimulated Monocyte Leukemia Cells. Cell Biochem Biophys . 2010 Nov 23. [Epub ahead of print] ( 通訊作者 ) 。
3. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Annals of Hematology 2010; 89(5):1089–1097. (通訊作者)
4. Down-Regulation of Telomerase Activity and Activation of Caspase Are Responsible for Tanshinone I-Induced Apoptosis in Monocyte Leukemia Cells. International Journal of Molecular Sciences 2010; 11(5): 2267-2280.
5. Activation of peroxisome proliferator-activated receptor-gamma induces apoptosis on acute promyelocyti leukemia cells via downregulation of XIAP. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2009; 24(5): 623-632.
6. Peroxisome Proliferator-Activated Receptor γ (PPAR-γ) Agonist Rosiglitazone (RGZ) Inhibits HL-60 Cell Growth by Induction of Apoptosis. Lab Medicine 2009; 40(5):297-302.
7. Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis. Oncology Reports 2009; 21(3): 1075-1081.
8. Peroxisome Proliferator-Activated Receptor-g Agonist Rosiglitazone–Induced Apoptosis in Leukemia K562 Cells and Its Mechanisms of Action. International Journal of Toxicology 2009; 28(2):123-131.
9. Ponicidin Inhibits Monocytic Leukemia Cell Growth by Induction of Apoptosis. International Journal of Molecular Sciences 2008 ; 9(11) : 2265-2277.
10. Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. Annals of Hematology 2007;86 (3):173-183.
11. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of Biomedical Science 2006; 13(12):813–823.
12. Antiproliferation Effects of Oridonin on HPB-ALL Cells and Its Mechanisms of Action. American Journal of Hematology 2006; 81(2):86–94.
13. Ponicidin, an Ent-Kaurane Diterpenoid Derived from a Constituent of the Herbal Supplement PC-SPES, Rabdosia rubescens , Induces Apoptosis by Activation of Caspase-3 and Mitochondrial Events in Lung Cancer Cells In Vitro. Cancer Investigation 2006; 24(2):136–148.
14. Expression of survivin and bax/bcl -2 in peroxisome proliferator activated receptor-{gamma} ligands induces apoptosis on human myeloid leukemia cells in vitro . Annals of Oncology 2005; 16(3):455-459.
15. Peroxisome proliferator activated receptor- ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. Cancer Chemotherapy and Pharmacology 2005;56(4):400-408.
16. Oridonin-induced apoptosis in leukemia K562 cells and its mechanism. Neoplasma 2005;52 (3):225-230.
17. Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro . Oncology Reports 2005; 13 (4):653-657.
18. Apoptotic effect of oridonin on NB4 cells and its mechanism. Leukemia & Lymphoma 2005; 46 (4): 593-597.
19. Antiproliferation effects of oridonin on HL-60 cells. Annals of Hematology 2004; 83(11):691-695.
20. Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. Journal of International Medical Research 2004; 32 (6):617-625.
21 . Oridonin Inhibit Cell Growth by Induction of Apoptosis on Human Carcinoma BEL7402 Cells.Hepatology Research . 2006;35(2)104-110.
22 . Oridonin-induced apoptosis of Jurkat cells and its mechanism. Comparative Pathology.2004;13(2): 65-69.
從事內(nèi)科血液學(xué)臨床醫(yī)療及科研工作近20年。多年以來從事白血病細(xì)胞凋亡
信號轉(zhuǎn)導(dǎo)機(jī)制、血液腫瘤的分子靶向治療及抗白血病藥物的作用靶點等研究。 目
前擔(dān)任歐洲國際著名SCI雜志 Anti-Cancer Drugs(2005年最新影響因子為:2.05)
編委(Editorial borad), 國家自然科學(xué)基金委評審專家、 廣東省自然基金委評審
專家?,F(xiàn)為美國血液學(xué)會會員,歐洲腫瘤協(xié)會抗癌分會國際會員,多年以來擔(dān)任
British Journal of Hematology,International Journal of Cancer,Oncology
等著名SCI雜志特約審稿人(Peer Reviewer)。曾經(jīng)參與完成國家自然科學(xué)基金
2項,省自然科學(xué)基金4項。
截至到目前為止,在國內(nèi)外核心期刊發(fā)表論文50余篇(第一作者), 其中SCI收
錄14篇。 2006-2007年以來被美國 Who\'s who in The Medicine and Healthcare
(世界醫(yī)學(xué)與健康護(hù)理名人錄)收錄。 2004年榮獲中山大學(xué)附屬三院優(yōu)秀中青年醫(yī)
師獎。是中山大學(xué)“千百十人才工程”培養(yǎng)對象。 2006年科研課題榮獲教育部“新
世紀(jì)優(yōu)秀人才支持計劃”資助。 多年來發(fā)表的一系列研究成果被國際醫(yī)學(xué)權(quán)威研究
機(jī)構(gòu) complementary and Alternative Medicine Research 收錄。